PDE4D phosphorylation: A coincidence detector integrating

pede4dPhosphodiesterase 4D (PDE4D) expression is upregulated in angiotensin (Ang) II-induced hypertensive mice. We first established a hypertensive model in wild-type (WT,Pharmacological phosphodiesterase 4D (PDE4D) inhibition shows therapeutic potential to restore memory function in Alzheimer's disease (AD), but will likely evoke adverse side effects. As